Mankhwala a crystal akupanga kafukufuku komanso kuwunika kosasinthika

Kuwunika kwapaintaneti kumapereka zotsatira zachangu pakuyezetsa kwa kristalo, deta yosalekeza imathandizira njira zamachitidwe ndi zomaliza, kupereka kukhathamiritsa, mayendedwe.

Mitundu yosiyanasiyana ya kristalo ya mankhwala omwewo ikhoza kusonyeza kusiyana kwakukulu kwa maonekedwe, kusungunuka, kusungunuka, kusungunuka, kusungunuka, bioavailability, etc.Choncho, m'pofunika kutsimikizira kukhalapo kwa chandamale kristalo mawonekedwe pa kaphatikizidwe mankhwala ndi mapangidwe njira.

M`kati kupanga latsopano mankhwala, m`pofunika kuwunika mu zenizeni nthawi crystalline gawo zikuchokera mankhwala mu kaphatikizidwe anachita njira.Izi zimachitidwa kuti ziwongolere ndondomekoyi ndikuwonetsetsa kuti chandamale cha crystalline cha mankhwala chikupangidwa.Raman spectroscopy angagwiritsidwe ntchito kuwunika mu-situ, kupereka zenizeni nthawi kusanthula crystalline gawo zikuchokera mankhwala kaphatikizidwe anachita, makamaka oyenera kusanthula mwatsatanetsatane kachitidwe polymorphic ndi amorphous API munali.

Makanema a pa intaneti a Raman amawongolera kuwunika kwa gawo la kristalo pazosiyanasiyana zomwe zimachitika, monga momwe kampani yopangira mankhwala imayesa magulu opangira mankhwala.Zotsatirazo zinatsimikizira kugwirizanitsa ndi mankhwala omwe amagwiritsidwa ntchito popanga mankhwala, kusonyeza kafukufuku wopambana.Zolepheretsa m'mbuyomu pogwiritsa ntchito XRD ndi zida zina za labu zidapangitsa kuti pakhale zovuta za data komanso kufalikira kwachitukuko.Mlandu wina udawonetsa kusiyanitsa kwanthawi yeniyeni kwa kusintha kwa gawo la kristalo munjira zisanu ndi imodzi, ndikupereka zidziwitso zaposachedwa pazotsatira zamalonda.